{"id":143,"date":"2021-05-23T11:31:17","date_gmt":"2021-05-23T09:31:17","guid":{"rendered":"http:\/\/symbivita.cz\/rovnovaha-zivota\/?p=143"},"modified":"2021-05-23T11:33:59","modified_gmt":"2021-05-23T09:33:59","slug":"kurkumin-jako-nutrigenetikum","status":"publish","type":"post","link":"https:\/\/symbivita.cz\/rovnovaha-zivota\/2021\/05\/23\/kurkumin-jako-nutrigenetikum\/","title":{"rendered":"Kurkumin jako nutrigenetikum"},"content":{"rendered":"\n

Kurkuma<\/strong> neboli indick\u00fd \u0161afr\u00e1n<\/strong> m\u00e1 p\u016fvod v ji\u017en\u00ed Asii. Zn\u00e1me ji jako sou\u010d\u00e1st kar\u00ed ko\u0159en\u00ed a pou\u017e\u00edv\u00e1me i samostatn\u011b. Zlato\u017elut\u00fd pr\u00e1\u0161ek z\u00edsk\u00e1van\u00fd z t\u00e9to rostliny se k l\u00e9\u010debn\u00fdm \u00fa\u010del\u016fm v zem\u00edch sv\u00e9ho p\u016fvodu pou\u017e\u00edv\u00e1 ji\u017e 4000 let. Z kurkumy se z\u00edsk\u00e1v\u00e1 kurkumin, co\u017e je ono \u017elut\u00e9 barvivo, flavonoid.<\/p>\n\n\n\n

\"\"<\/figure>\n\n\n\n

\u00da\u010del pou\u017eit\u00ed<\/strong><\/p>\n\n\n\n

Dle lidov\u00fdch tradic se kurkuma objevuje v receptech\npro l\u00e9\u010den\u00ed <\/em><\/strong><\/p>\n\n\n\n

  • nemoc\u00ed tr\u00e1vic\u00ed soustavy, <\/em><\/li>
  • jater a <\/em><\/li>
  • \u017elu\u010dn\u00edku, <\/em><\/li>
  • \u017eloutenky, <\/em><\/li>
  • kardiovaskul\u00e1rn\u00edho syst\u00e9mu, <\/em><\/li>
  • p\u0159i bolestiv\u00e9 menstruaci <\/em><\/li>
  • a v\u0161ude tam, kde prob\u00edhaj\u00ed z\u00e1n\u011bty, <\/em><\/li>
  • infekce. <\/em><\/li>
  • Podporuje imunitu, <\/em><\/li>
  • regeneraci, <\/em><\/li>
  • zpomaluje proces st\u00e1rnut\u00ed, nejv\u00edce je zn\u00e1ma\njako\u017eto <\/em><\/li>
  • \u00fa\u010dinn\u00fd antioxidant.<\/em><\/li><\/ul>\n\n\n\n

    V\u011bdeck\u00e9 b\u00e1d\u00e1n\u00ed <\/strong><\/p>\n\n\n\n

    se soust\u0159ed\u00ed na vyu\u017eit\u00ed kurkuminu v l\u00e9\u010den\u00ed\nr\u016fzn\u00fdch typ\u016f rakovin<\/em><\/strong>. Tyto pr\u00e1ce sleduj\u00ed \u00fa\u010dinek kurkumy v p\u0159\u00edpadech\nrakoviny slinivky, p\u0159i sni\u017eov\u00e1n\u00ed PSA, co\u017e je ukazatel rozvoje rakoviny prostaty,\nu pacient\u016f s kolorekt\u00e1ln\u00edm karcinomem. Sleduje se vliv na potla\u010dov\u00e1n\u00ed\nmetast\u00e1z u rakoviny prostaty, plic.<\/p>\n\n\n\n

    Dodatek: Za<\/em> rizikov\u00e9\nfaktory<\/em><\/strong> vzniku rakoviny<\/em> jsou pova\u017eov\u00e1ny konzumace alkoholu, kou\u0159en\u00ed,\nnadm\u011brn\u00fd p\u0159\u00edjem soli, nadv\u00e1ha, nedostate\u010dn\u00e1 aktivita a konzumace \u010derven\u00e9ho,\nuzen\u00e9ho a grilovan\u00e9ho masa<\/em><\/strong>.<\/p>\n\n\n\n

    Zaj\u00edmav\u00e9 pr\u00e1ce sleduj\u00ed synergick\u00fd \u00fa\u010dinek<\/em><\/strong> kurkuminu s chemoterapi\u00ed u <\/em><\/p>\n\n\n\n

    • rakoviny d\u011blo\u017en\u00edho \u010d\u00edpku, prsu, tlust\u00e9ho\nst\u0159eva. <\/em><\/li><\/ul>\n\n\n\n

      Ukazuje se, \u017ee sou\u010dinnost kurkuminu\np\u0159in\u00e1\u0161\u00ed m\u00e9n\u011b vedlej\u0161\u00edch projev\u016f chemoterapie. <\/p>\n\n\n\n

      Zkou\u0161\u00ed se pod\u00e1vat kurkumin v prevenci n\u011bkter\u00fdch typ\u016f\nschizofrenie, u adenom\u016f a polyp\u016f.<\/p>\n\n\n\n

      Preventivn\u00ed\n\u00fa\u010dinek kurkuminu je zkoum\u00e1n u z\u00e1va\u017en\u00fdch metabolick\u00fdch a kardiovaskul\u00e1rn\u00edch\nonemocn\u011bn\u00ed, u diabetu a tak\u00e9 u depres\u00ed, proto\u017ee zvy\u0161uje koncentraci\nbeta-endorfin\u016f a serotoninu v mozku, a tento efekt se m\u016f\u017ee dostavit pr\u00e1v\u011b\nzlep\u0161en\u00edm biologick\u00e9ho vyu\u017eit\u00ed pomoc\u00ed kombinace kurkuminu a piperinu <\/em><\/strong>jako\np\u0159\u00edrodn\u00edho antidepresiva.<\/strong><\/em>St\u00e1le v\u0161ak nen\u00ed objasn\u011bno, pro\u010d\nhladina serotoninu kles\u00e1\u2026<\/strong><\/p>\n\n\n\n

      Nov\u00e9 pozn\u00e1n\u00ed v oblasti epigenetiky<\/em><\/strong> poskytuje d\u016fle\u017eit\u00e9\nzji\u0161t\u011bn\u00ed, \u017ee vlivy vn\u011bj\u0161\u00edho prost\u0159ed\u00ed, nap\u0159.\nv\u00fd\u017eiva, mohou z\u00e1sadn\u00edm zp\u016fsobem zm\u011bnit aktivitu gen\u016f \u0159\u00edd\u00edc\u00edch \u010dinnost mozku<\/em>.\nJe to obecn\u011b pova\u017eov\u00e1no za jeden z nejv\u011bt\u0161\u00edch objev\u016f ve v\u00fdzkumu mozku za\nposledn\u00edch deset let.<\/p>\n\n\n\n

      A na objevy epigenetiky navazuje i obor zvan\u00fd nutrigenetika<\/em><\/strong>.\nTa kombinuje molekul\u00e1rn\u00ed genetiku s naukou o zdrav\u00e9 v\u00fd\u017eiv\u011b. Naz\u00fdv\u00e1 se tak\u00e9\nmolekul\u00e1rn\u00ed nutriciologie<\/em><\/strong>. Jej\u00edm c\u00edlem je sledovat vliv genov\u00fdch polymorfizm\u016f\n(pro jeden znak existuj\u00ed dv\u011b genetick\u00e9 varianty) na metabolick\u00e9 \u00fa\u010dinky\njednotliv\u00fdch slo\u017eek stravy, s c\u00edlem vypracovat individu\u00e1ln\u00ed dietn\u00ed doporu\u010den\u00ed\npro prevenci a l\u00e9\u010dbu metabolick\u00fdch poruch. <\/p>\n\n\n\n

      Aby byla informace kompletn\u00ed, je t\u0159eba zm\u00ednit pojem nutrigenomika<\/em><\/strong>.\nTa zkoum\u00e1 mechanizmy, jimi\u017e nutri\u010dn\u00ed faktory ovliv\u0148uj\u00ed expresi<\/em> gen\u016f a regula\u010dn\u00ed\nfunkce<\/em> genov\u00fdch produkt\u016f\u2026 (Exprese genu je\nproces, kter\u00fdm je v genu ulo\u017een\u00e1 informace p\u0159evedena v bun\u011b\u010dnou strukturu –\nprotein nebo funkci.)<\/p>\n\n\n\n

      Kurkumin<\/strong>\nnedok\u00e1\u017ee p\u0159\u00edmo ovlivnit DNA, to ani neo\u010dek\u00e1v\u00e1me, ale <\/p>\n\n\n\n

      • m\u016f\u017ee zasahovat prost\u0159ednictv\u00edm zji\u0161t\u011bn\u00fdch\nepigenetick\u00fdch mechanizm\u016f, jako je metylace DNA, acetylace, modifikace histon\u016f,\nzm\u011bny miRNA, a t\u00edm ovlivn\u00ed, kter\u00fd gen se\nprojev\u00ed a kter\u00fd nikoliv<\/strong><\/em>, kter\u00fd gen se zapne nap\u0159. pro rakovinu a\nkter\u00fd naopak rakovinn\u00fd proces vypne.<\/li><\/ul>\n\n\n\n

        V biochemii rozli\u0161ujeme skupinu enzym\u016f s n\u00e1zvem\nDNA methyltransfer\u00e1za (DNA MT\u00e1za, DNMT…), kter\u00e1 katalyzuje p\u0159enos methylov\u00e9\nskupiny na DNA. Methylace\nDNA slou\u017e\u00ed \u0161irok\u00e9 \u0161k\u00e1le biologick\u00fdch funkc\u00ed. V\u0161echny\nzn\u00e1m\u00e9 DNA methyltransfer\u00e1zy pou\u017e\u00edvaj\u00ed jako donor methylu S-adenosyl methionin\n(SAM).<\/p>\n\n\n\n

        Kurkumin se \u0159ad\u00ed mezi epigeneticky aktivn\u00ed\nslou\u010deniny -fytoslou\u010deniny.<\/p>\n\n\n\n

        Jak<\/em><\/strong> je kurkumin<\/em> uveden\u00fdm kontroln\u00edm syst\u00e9mem pou\u017e\u00edv\u00e1n<\/em>? Pomoc\u00ed metylace DNA se pou\u017eije cytosin, jedna z nukleob\u00e1z\u00ed, a do n\u00ed se vprav\u00ed methylenov\u00e1 skupina, jak ukazuje obr\u00e1zek\u2026<\/p>\n\n\n\n

        \"\"<\/figure>\n\n\n\n

        T\u00edm vznikne situace, kter\u00e1\nznemo\u017en\u00ed vyj\u00e1d\u0159en\u00ed genu; podstatou je, \u017ee \u00fasek DNA je st\u00e1le p\u0159\u00edtomen, ale t\u011blo\nho nedok\u00e1\u017ee uplatnit. <\/p>\n\n\n\n

        Funguje jako DNMT inhibitor<\/strong><\/p>\n\n\n\n

        V\u011bdci popsali souvislosti methylace DNA n\u011bkolika d\u016fle\u017eit\u00fdch\ngen\u016f u \u0161irok\u00e9 \u0161k\u00e1ly onemocn\u011bn\u00ed, kdy je jeden nebo v\u00edce gen\u016f potla\u010deno v d\u016fsledku\nzv\u00fd\u0161en\u00e9 methylace a takov\u00e9 situace m\u016f\u017ee pomoci ovliv\u0148ovat kurkumin  jako DNMT inhibitor.<\/p>\n\n\n\n

        (<\/em>Inhibice je v biochemii proces, kdy vazba ur\u010dit\u00e9\nl\u00e1tky zp\u016fsob\u00ed sn\u00ed\u017een\u00ed aktivity enzymu. T\u00edm doch\u00e1z\u00ed k zamezen\u00ed \u010di omezen\u00ed\nspr\u00e1vn\u00e9ho pr\u016fb\u011bhu enzymatick\u00e9 reakce. L\u00e1tky, kter\u00e9 takto \u00fa\u010dinkuj\u00ed, se ozna\u010duj\u00ed\njako enzymatick\u00e9 inhibitory \u010di negativn\u00ed efektory.)<\/em><\/em><\/p>\n\n\n\n

        Je tak\u00e9 zn\u00e1mo, \u017ee methylace DNA hraje d\u016fle\u017eitou roli p\u0159i n\u011bkolika dal\u0161\u00edch poruch\u00e1ch, jako je cukrovka, neurokognitivn\u00ed onemocn\u011bn\u00ed, autoimunitn\u00ed poruchy a z\u00e1n\u011btliv\u00e9 poruchy.<\/p>\n\n\n\n

        \"\"<\/figure><\/div>\n\n\n\n

        Ovliv\u0148uje miRNA<\/strong><\/p>\n\n\n\n

        Kurkumin<\/strong> m\u00e1 vliv\ntak\u00e9 na micro RNA<\/em><\/strong> (miRNA), mal\u00e9 nek\u00f3duj\u00edc\u00ed\nmolekuly RNA. <\/p>\n\n\n\n

        Ty maj\u00ed asi 22 nukleotid\u016f,\nne\u00fa\u010dastn\u00ed se tvorby b\u00edlkovin, ale maj\u00ed roli v programov\u00e1n\u00ed bun\u011b\u010dn\u00e9 smrti<\/em><\/strong> bun\u011bk. Samoz\u0159ejm\u011b se to t\u00fdk\u00e1 tak\u00e9\nrakovinn\u00fdch bun\u011bk<\/em>. A kurkumin pr\u00e1v\u011b p\u016fsoben\u00edm na micro RNA pom\u00e1h\u00e1\novliv\u0148ovat mno\u017een\u00ed rakovinn\u00fdch bun\u011bk.<\/p>\n\n\n\n

        Dal\u0161\u00ed p\u0159\u00edzniv\u00e9 vlivy<\/strong><\/p>\n\n\n\n

        Sni\u017euje expresi \u0159ady gen\u016f, kter\u00e9 se pod\u00edlej\u00ed na zes\u00edlen\u00ed z\u00e1n\u011btu\nse vztahem k rozvoji nap\u0159. Alzheimerovy choroby, karcinomu a ischemick\u00e9\nchoroby srde\u010dn\u00ed.<\/p>\n\n\n\n

        Je zaj\u00edmav\u00e9 zm\u00ednit, \u017ee Indie m\u00e1 nejni\u017e\u0161\u00ed tendence k Alzheimerov\u011b\nchorob\u011b na sv\u011bt\u011b.<\/p>\n\n\n\n

        Kurkumin pozitivn\u011b ovliv\u0148uje mnoh\u00e9 enzymy, transkrip\u010dn\u00ed faktory,\nz\u00e1n\u011btliv\u00e9 cytokiny, kin\u00e1zy, r\u016fstov\u00e9 faktory, receptory a mnoh\u00e9 dal\u0161\u00ed\nmechanismy.<\/p>\n\n\n\n

        V\u011bdeck\u00e9 pr\u00e1ce tak\u00e9 potvrzuj\u00ed lidov\u00e9 zku\u0161enosti o \u00fa\u010dinku kurkuminu<\/strong> v p\u0159\u00edpad\u011b kardiovaskul\u00e1rn\u00edch\nchorob<\/em><\/strong> (KV). Sleduje se \u00fa\u010dinek na sni\u017eov\u00e1n\u00ed tvorby aterosklerotick\u00fdch\npl\u00e1t\u016f a na sni\u017eov\u00e1n\u00ed cholesterolu. V prevenci t\u011bchto nemoc\u00ed hraje d\u016fle\u017eitou\nroli i jeho epigenetick\u00e9 p\u016fsoben\u00ed: Epidemiologick\u00e9 studie uskute\u010dn\u011bn\u00e9 ve druh\u00e9\npolovin\u011b minul\u00e9ho stolet\u00ed prok\u00e1zaly v\u00fdznamn\u00fd pod\u00edl pozitivn\u00ed rodinn\u00e9 anamn\u00e9zy\nna celkov\u00e9m riziku kardiovaskul\u00e1rn\u00edch chorob (KV), a to manifestac\u00ed\nateroskler\u00f3zy. Chyb\u011blo v\u0161ak vysv\u011btlen\u00ed, pro\u010d<\/em> se tak d\u011bje.<\/p>\n\n\n\n

        V sou\u010dasn\u00e9 dob\u011b p\u0159ib\u00fdv\u00e1 epidemiologick\u00fdch prac\u00ed, je\u017e prokazuj\u00ed\nv\u00fdznam n\u011bkter\u00fdch genov\u00fdch polymorfizm\u016f pro nar\u016fstaj\u00edc\u00ed rizika ischemick\u00e9\nchoroby srde\u010dn\u00ed (ICHS).<\/p>\n\n\n\n

             Pozn\u00e1mka 1<\/strong>: Pro\nFrancouze je sice charakteristick\u00fd vysok\u00fd p\u0159\u00edjem tuk\u016f ve strav\u011b, p\u0159esto maj\u00ed\nstatisticky ni\u017e\u0161\u00ed \u00famrtnost zp\u016fsobenou kardiovaskul\u00e1rn\u00edmi nemocemi. Tato\nanom\u00e1lie se p\u0159ipisuje vy\u0161\u0161\u00ed konzumaci \u010derven\u00e9ho v\u00edna. <\/p>\n\n\n\n

        \u010cerven\u00e9 v\u00edno obsahuje \u0159adu zdrav\u00ed prosp\u011b\u0161n\u00fdch l\u00e1tek. Mezi\nhlavn\u00ed pat\u0159\u00ed polyfenolick\u00e9 l\u00e1tky (resveratrol, quercetin, katechin,\nepikatechin, kaemferol, kyselina gallov\u00e1, protokachetov\u00e1), antokyany,\nprokyanidy a dal\u0161\u00ed.<\/p>\n\n\n\n

        Kurkumin<\/strong> zlep\u0161uje\nfunkci beta-bun\u011bk slinivky, kter\u00e9 produkuj\u00ed inzulin, a v\u00fdzkumy ukazuj\u00ed, \u017ee\nsni\u017euje inzulinovou rezistenci.<\/p>\n\n\n\n

             Pozn\u00e1mka 2<\/strong>: Jako\nprevence diabetu se doporu\u010duje pravideln\u00fd p\u0159\u00edsun pestr\u00e9 stravy s dostate\u010dn\u00fdm\nmno\u017estv\u00edm vl\u00e1kniny a potravin s n\u00edzk\u00fdm glykemick\u00fdm indexem (ten ud\u00e1v\u00e1 rychlost\nvyu\u017eit\u00ed gluk\u00f3zy t\u011blem z ur\u010dit\u00e9 potraviny), jako je zelenina, m\u00e9n\u011b sladk\u00e9 ovoce,\ncelozrnn\u00e9 pe\u010divo, polotu\u010dn\u00e9 ml\u00e9ko, lu\u0161t\u011bniny, s\u00f3jov\u00e9 boby atd.<\/p>\n\n\n\n

        Z oblasti epigenetiky<\/strong><\/p>\n\n\n\n

        je zaj\u00edmav\u00fd fakt, \u017ee u ob\u00e9zn\u00edch lid\u00ed jsou velmi \u010dasto\np\u0159\u00edtomny epigenetick\u00e9 zm\u011bny typu metylace DNA \u010di zm\u011bny modifikace histon\u016f\nv oblasti gen\u016f, je\u017e jsou odpov\u011bdn\u00e9 za tvorbu tukov\u00e9 tk\u00e1n\u011b. Jin\u00fdmi slovy, ob\u00e9zn\u00ed lid\u00e9 maj\u00ed zapnut\u00fd gen pro tvorbu tukov\u00e9 tk\u00e1n\u011b<\/strong> (obezogen<\/strong><\/em>)<\/strong>. Tento term\u00edn v prvn\u00edm desetilet\u00ed\ntohoto stolet\u00ed pou\u017eil na Kalifornsk\u00e9 univerzit\u011b biolog Blumberg pot\u00e9, co\nprov\u00e1d\u011bl studie na my\u0161\u00edch. Pod\u00e1val b\u0159ez\u00edm my\u0161\u00edm slou\u010deninu c\u00ednu. Samic\u00edm se\npotom rodila v\u011bt\u0161\u00ed ml\u00e1\u010fata se sklonem k p\u0159ib\u00fdv\u00e1n\u00ed na v\u00e1ze. A d\u00e1le zjistil,\n\u017ee jejich tukov\u00e9 bu\u0148ky jsou v\u011bt\u0161\u00ed. <\/p>\n\n\n\n

        Mezi tzv.\nobezitogeny<\/strong><\/em> se \u0159ad\u00ed <\/p>\n\n\n\n

        • n\u011bkter\u00e9 ochrann\u00e9 barvy<\/em> d\u0159ev\u011bn\u00fdch konstrukc\u00ed, n\u011bkter\u00e9 insekticidy, herbicidy<\/em> a, \u017eel, dle n\u011bkter\u00fdch pramen\u016f i diskutovan\u00fd glutam\u00e1t sodn\u00fd<\/em>, d\u00e1le i l\u00e1tky, je\u017e se podobaj\u00ed \u017eensk\u00e9mu estrogenu,\nt\u0159eba genistein<\/em>. A co nap\u0159. produkty z vojt\u011b\u0161ky\na s\u00f3ji<\/em>?<\/em><\/li><\/ul>\n\n\n\n

          A\nkurkumin pat\u0159\u00ed mezi substance, kter\u00e9 ovliv\u0148uj\u00ed funkci gen\u016f odpov\u011bdn\u00fdch za\nukl\u00e1d\u00e1n\u00ed tuk\u016f\u2026<\/em><\/p>\n\n\n\n

               Pozn\u00e1mka 3<\/strong>:\nKonjugovan\u00e1 kyselina linolov\u00e1 CLA prok\u00e1zala antioxida\u010dn\u00ed, antiobezitn\u00ed,\nantidiabetickou, antikarcinogenn\u00ed a imunomodula\u010dn\u00ed aktivitu. P\u0159i studi\u00edch na\nlaboratorn\u00edch my\u0161\u00edch se prok\u00e1zalo, \u017ee sm\u011bs izomer\u016f CLA sni\u017euje mno\u017estv\u00ed\nt\u011blesn\u00e9ho tuku a navy\u0161uje mno\u017estv\u00ed svalov\u00e9 hmoty. <\/em>Podobn\u00e9 v\u00fdsledky p\u0159inesly\ni n\u011bkter\u00e9 klinick\u00e9 studie, prov\u00e1d\u011bn\u00e9 na zdrav\u00fdch i ob\u00e9zn\u00edch jedinc\u00edch.<\/p>\n\n\n\n

               Pozn\u00e1mka 4<\/strong>: Kurkumin a chronick\u00e9 degenerativn\u00ed procesy\ntypu artr\u00f3za. Ta pat\u0159\u00ed mezi nej\u010dast\u011bj\u0161\u00ed\nonemocn\u011bn\u00ed kloub\u016f u dosp\u011bl\u00fdch lid\u00ed, podle statistik postihuje v\u00edce ne\u017e 50 %\nosob star\u0161\u00edch 65 let. M\u016f\u017ee se t\u00fdkat kter\u00e9hokoliv kloubu v t\u011ble, nej\u010dast\u011bji\nje posti\u017eena p\u00e1te\u0159, kolena a ky\u010dle. Dominantn\u00edm p\u0159\u00edznakem je bolest, postupn\u011b\nv\u0161ak doch\u00e1z\u00ed i k omezen\u00ed hybnosti a trval\u00fdm poruch\u00e1m posti\u017een\u00fdch kloub\u016f.<\/p>\n\n\n\n

          Sou\u010dasn\u00e1 medic\u00edna nedok\u00e1\u017ee artr\u00f3zu vyl\u00e9\u010dit, dok\u00e1\u017ee ov\u0161em\nzpomalit jej\u00ed pr\u016fb\u011bh. Jednu z mo\u017enost\u00ed l\u00e9\u010dby p\u0159edstavuj\u00ed takzvan\u00e1 fytofarmaka<\/em><\/strong>.\nJedn\u00e1 se o skupinu l\u00e9\u010div\u00fdch l\u00e1tek na p\u0159\u00edrodn\u00ed b\u00e1zi; sni\u017euj\u00ed z\u00e1n\u011bt a vy\u017eivuj\u00ed\nchrupavku.<\/p>\n\n\n\n

          V\u00fdhodou kurkuminu <\/strong><\/p>\n\n\n\n

          je, \u017ee krom\u011b zpomalen\u00ed \u00fabytku chrupavky<\/em> rovn\u011b\u017e tlum\u00ed\nz\u00e1n\u011bt v kloubu<\/em>, a tak p\u0159isp\u00edv\u00e1 ke zlep\u0161en\u00ed obt\u00ed\u017e\u00ed. Kurkumin lze p\u0159itom\nu\u017e\u00edvat dlouhodob\u011b, nem\u00e1 prakticky \u017e\u00e1dn\u00e9 vedlej\u0161\u00ed \u00fa\u010dinky.<\/p>\n\n\n\n

          Kurkumin lze p\u0159id\u00e1vat do\nstravy p\u0159\u00edmo formou pr\u00e1\u0161kov\u00e9 kurkumy nebo ve sm\u011bsi ko\u0159en\u00ed \u201ekari\u201c. <\/p>\n\n\n\n

          V\u00fdhodn\u011bj\u0161\u00ed varianta spo\u010d\u00edv\u00e1 v ka\u017edodenn\u00edm\npou\u017eit\u00ed koncentrovan\u00e9ho potravn\u00edho dopl\u0148ku<\/em>. <\/p>\n\n\n\n

          Kurkumin je \u0161patn\u011b rozpustn\u00fd ve vod\u011b, v\u00e1\u017ee se na tuky<\/em>, proto se doporu\u010duje jeho u\u017e\u00edv\u00e1n\u00ed sou\u010dasn\u011b s j\u00eddlem. <\/p>\n\n\n\n

          \"\"<\/figure>\n\n\n\n

          Podle rozsahu v\u011bdeck\u00fdch prac\u00ed\nv\u011bnuj\u00edc\u00edch velkou pozornost studiu nutrigenetiky lze o\u010dek\u00e1vat, \u017ee tento v\u00fdzkum umo\u017en\u00ed vypracovat sm\u011brnice pro\nindividu\u00e1ln\u00ed dietn\u00ed prevenci a l\u00e9\u010dbu z\u00e1va\u017en\u00fdch metabolick\u00fdch a\nkardiovaskul\u00e1rn\u00edch onemocn\u011bn\u00ed, jako jsou poruchy tukov\u00e9ho metabolizmu, obezita,\ndiabetes, ICHS a n\u00e1dorov\u00e1 onemocn\u011bn\u00ed. <\/em><\/p>\n\n\n\n

          > Sv\u011btov\u00e1\nzdravotnick\u00e1 organizace spolu s prominentn\u00edmi v\u011bdeck\u00fdmi institucemi pova\u017euje nutrigenetick\u00fd\nv\u00fdzkum za prioritu 21. stolet\u00ed<\/em><\/strong>.<\/p>\n\n\n\n

          Zasluhuj\u00ed pozornost<\/strong><\/p>\n\n\n\n

          \u010cl\u00e1nek se soust\u0159edil na kurkumin,\nale podobnou pozornost si zasluhuj\u00ed l\u00e1tky obsa\u017een\u00e9 v zelen\u00e9m \u010daji – epigallokatechingall\u00e1t\n<\/em><\/strong>(EGCG), epikatechin<\/em><\/strong> (EC), epikatechingall\u00e1t<\/em><\/strong>\n(ECG) a epigallokatechin<\/em><\/strong> (EGC), d\u00edky nim\u017e je konzumace zelen\u00e9ho\n\u010daje z pohledu nutrigenetiky prosp\u011b\u0161n\u00e1. A dal\u0161\u00ed. <\/p>\n\n\n\n

          Je vhodn\u00e9 zm\u00ednit i zelenou\nbrukvovitou zeleninu typu brokolice, kter\u00e1 je bohat\u00e1 na izothiokyanidy.\nGlutathion. <\/em><\/strong>O resveratrolu<\/em><\/strong> ji\u017e byla tak\u00e9 zm\u00ednka. <\/p>\n\n\n\n

          SAM-S-adenosyl-methionin<\/em><\/strong> je\nkoenzym mnoha methyla\u010dn\u00edch enzym\u016f. Je tzv. hlavn\u00ed d\u00e1rce methylov\u00e9 skupiny, je\nv\u0161ak v potravin\u00e1ch nestabiln\u00ed, proto je vyr\u00e1b\u011bn ve form\u011b potravn\u00edho dopl\u0148ku\nstravy.<\/p>\n\n\n\n

          Methionin<\/em><\/strong> (sezam,\n\u0161pen\u00e1t, ryby, para o\u0159echy, pep\u0159) \u2013 d\u016fle\u017eit\u00fd pro SAM synt\u00e9zu. Jeho v\u00fdrobu podporuje\nkyselina listov\u00e1<\/em> (slune\u010dnicov\u00e1 semena, listov\u00e1 zelenina, j\u00e1tra, dro\u017ed\u00ed), vitamin\nB12<\/em> (maso, j\u00e1tra, ryby), podobn\u011b i vitamin B6<\/em> (maso, celozrnn\u00e9\nv\u00fdrobky, zelenina, o\u0159echy). <\/p>\n\n\n\n

          Cholin<\/em><\/strong> (\u017eloutky,\nj\u00e1tra, s\u00f3ja, va\u0159en\u00e9 hov\u011bz\u00ed maso, ku\u0159ec\u00ed, telec\u00ed a kr\u016ft\u00ed), d\u00e1rce methylov\u00fdch\nskupin SAM. <\/p>\n\n\n\n

          Betain<\/em><\/strong> (p\u0161enice,\n\u0161pen\u00e1t, mo\u0159sk\u00e9 plody a \u010derven\u00e1 \u0159epa) sni\u017euje mno\u017estv\u00ed toxick\u00fdch l\u00e1tek prost\u0159ednictv\u00edm\nSAM.<\/p>\n\n\n\n

          Pustil jsem se do \u00favahy nad\u011bjn\u00fdch mo\u017enost\u00ed tzv. preventivn\u00ed medic\u00edny,<\/em> ale cht\u011bl bych zd\u016fraznit, \u017ee t\u00e9ma prevence je st\u00e1le stejn\u00e9: nekou\u0159it, udr\u017eovat si ide\u00e1ln\u00ed v\u00e1hu, j\u00edst vyrovnanou stravu, systematicky cvi\u010dit, redukovat stres.<\/p>\n\n\n\n

          \"\"<\/figure>\n\n\n\n

          MUDr. P. \u0160\u00e1cha<\/p>\n","protected":false},"excerpt":{"rendered":"

          l\u00e1nek se zam\u00fd\u0161l\u00ed pouze nad potenci\u00e1ln\u00edmi \u00fa\u010dinky, kter\u00e9 kurkumin \u0159ad\u00ed mezi nutrigenetika.<\/p>\n","protected":false},"author":1,"featured_media":142,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4],"tags":[],"_links":{"self":[{"href":"https:\/\/symbivita.cz\/rovnovaha-zivota\/wp-json\/wp\/v2\/posts\/143"}],"collection":[{"href":"https:\/\/symbivita.cz\/rovnovaha-zivota\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/symbivita.cz\/rovnovaha-zivota\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/symbivita.cz\/rovnovaha-zivota\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/symbivita.cz\/rovnovaha-zivota\/wp-json\/wp\/v2\/comments?post=143"}],"version-history":[{"count":2,"href":"https:\/\/symbivita.cz\/rovnovaha-zivota\/wp-json\/wp\/v2\/posts\/143\/revisions"}],"predecessor-version":[{"id":151,"href":"https:\/\/symbivita.cz\/rovnovaha-zivota\/wp-json\/wp\/v2\/posts\/143\/revisions\/151"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/symbivita.cz\/rovnovaha-zivota\/wp-json\/wp\/v2\/media\/142"}],"wp:attachment":[{"href":"https:\/\/symbivita.cz\/rovnovaha-zivota\/wp-json\/wp\/v2\/media?parent=143"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/symbivita.cz\/rovnovaha-zivota\/wp-json\/wp\/v2\/categories?post=143"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/symbivita.cz\/rovnovaha-zivota\/wp-json\/wp\/v2\/tags?post=143"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}